_optimisation-of-nanb-inhibitiors-based-upon-ches-part-3.jpg "Optimisation of NanB Inhibitiors based upon CHES part 3 from nanb Video Screenshot Preview")
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⏲ Duration: 49 sec
✓ Published: 21-Aug-2016
✓ Published: 21-Aug-2016
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This is Part 3 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem ). The structures detailing the optimization of the 4'-position of the phenyl ring. Cl causes the Met to move slightly enlarging the hydrophobic pocket, but also forms a halogen bond interaction with the Met leading to and increase in affinity. Whereas in order to accommodate MeO in the 4'
This is Part 3 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem ). The structures detailing the optimization of the 4'-position of the phenyl ring. Cl causes the Met to move slightly enlarging the hydrophobic pocket, but also forms a halogen bond interaction with the Met leading to and increase in affinity. Whereas in order to accommodate MeO in the 4'
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