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✓ Published: 07-Jun-2024
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_man-diagnosed-with-stage-four-testicular-cancer-completes-half-marathon.webp "A man who was diagnosed with stage four testicular cancer completed a half-marathon.<br/><br/>Callan Rogers, 28, ran a half-marathon in March despite being about to enter his sixth round of chemotherapy treatment.<br/><br/>Callan, from Stratford in London, was diagnosed at the age of 26.<br/><br/>When his latest round of treatment stopped working, he decided to run a half-marathon and completed it in two hours and 29 minutes.<br/><br/>Callan, a fire safety officer, said: \")
_vitamin-e-health-benefits.webp "Vitamin E is a nutrient that's important to vision, reproduction, and the health of your blood, brain and skin.<br/><br/>Vitamin E also has antioxidant properties. Antioxidants are substances that might protect your cells against the effects of free radicals — molecules produced when your body breaks down food or is exposed to tobacco smoke and radiation. Free radicals might play a role in heart disease, cancer and other diseases. If you take vitamin E for its antioxidant properties, keep in mind that the supplement might not offer the same benefits as naturally occurring antioxidants in food.<br/><br/>Foods rich in vitamin E include canola oil, olive oil, margarine, almonds and peanuts. You can also get vitamin E from meats, dairy, leafy greens and fortified cereals. Vitamin E is also available as an oral supplement in capsules or drops.<br/><br/>Vitamin E deficiency can cause nerve pain (neuropathy).<br/><br/>The recommended daily amount of vitamin E for adults is 15 milligrams a day.<br/><br/>What the research says<br/>Research on vitamin E use for specific conditions shows:<br/><br/>Alzheimer's disease. Some research has shown that high-dose vitamin E might delay the progression of Alzheimer's disease in people who have been diagnosed with mild to moderate Alzheimer's disease. Other studies haven't shown this benefit. Vitamin E supplements appear to have no effect on whether people with mild cognitive impairment progress to Alzheimer's disease.<br/>Liver disease. Studies show that vitamin E might improve symptoms of nonalcoholic fatty liver disease. However, some evidence suggests that taking oral vitamin E for this purpose for two years is linked to insulin resistance.<br/>Preeclampsia. Increasing your intake of vitamin E hasn't been shown to prevent this pregnancy condition that affects blood pressure.<br/>Prostate cancer. Research shows that vitamin E and selenium supplements don't prevent prostate cancer. There is also concern that use of vitamin E supplements might increase the risk of prostate cancer.<br/>Our take<br/>Yellow light: Caution<br/>Caution<br/>Most people get enough vitamin E from a balanced diet. If you've been diagnosed with mild to moderate Alzheimer's disease, some research suggests that vitamin E therapy might help slow disease progression.<br/><br/>However, oral use of vitamin E might increase the risk of prostate cancer. Use of the supplement can pose other serious risks, particularly at high doses and if you have other health conditions or have had a heart attack or stroke.<br/><br/>Safety and side effects<br/>When taken at appropriate doses, oral use of vitamin E is generally considered safe. Rarely, oral use of vitamin E can cause:<br/><br/>Nausea<br/>Diarrhea<br/>Intestinal cramps<br/>Fatigue<br/>Weakness<br/>Headache<br/>Blurred vision<br/>Rash<br/>Gonadal dysfunction<br/>Increased concentration of creatine in the urine (creatinuria)<br/>Taking higher doses of vitamin E might increase the risk of side effects. Also, there is concern that people in poor health who take high doses of vitamin E are at increased risk of death.")
_fruits-fitness-benefits.webp "Here are 10 benefits of watermelon:<br/><br/>1. Hydration: Watermelon is made up of about 92% water, making it an excellent source of hydration, particularly during hot summer months.<br/><br/>2. Antioxidants: Watermelon contains vitamin C and lycopene, two powerful antioxidants that help protect cells from damage and reduce the risk of chronic diseases.<br/><br/>3. Anti-Inflammatory: Watermelon contains anti-inflammatory compounds like citrulline and lycopene, which may help reduce inflammation and alleviate conditions like arthritis.<br/><br/>4. Digestive Health: Watermelon contains fiber and water, making it a great food for promoting healthy digestion and preventing constipation.<br/><br/>5. Weight Management: Watermelon is low in calories and high in fiber and water content, making it a great addition to a weight loss diet.<br/><br/>6. Anti-Cancer Properties: The antioxidants and anti-inflammatory compounds in watermelon may help reduce the risk of certain cancers, such as colon, breast, and prostate cancer.<br/><br/>7. Muscle Relief: Watermelon contains citrulline, an amino acid that may help reduce muscle soreness and improve exercise performance.<br/><br/>8. Skin and Hair Benefits: Watermelon contains vitamin A and C, which may help promote healthy skin and hair.<br/><br/>9. Eye Health: Watermelon contains vitamin A, which is essential for healthy vision and may help reduce the risk of age-related macular degeneration.<br/><br/>10. Supports Healthy Blood Pressure: The potassium content in watermelon may help lower blood pressure and reduce the risk of cardiovascular disease.<br/><br/>Enjoy your watermelon!")
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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. 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