Optimisation of NanB Inhibitiors based upon CHES part 2 from nanb Watch Video
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Description: This is Part 2 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem). The active site of NanB is covered by a flexible loop. This loop is normally held in position by a well defined water. In the structure with taurine the water can be seen and the loop is rigid, as can be seen from the B-factor putty representation (increased size and red means larger B-f
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