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![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.jpg "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
⏲ 1:31 👁 14.6M
_pro-trump-media-sphere-imploding-in-comparison-to-2016-election-cycle.jpg "The pro-Trump media landscape is experiencing a significant decline compared to the last election cycle, according to a recent report. In the lead-up to the 2016 presidential election, numerous far-right websites emerged and profited from content that supported then-candidate Donald Trump. These sites continued to generate millions of dollars during Trump's time in office. However, since the 2020 election, the flow of traffic and revenue for these right-wing media outlets has dramatically decreased. This decline can largely be attributed to changes in Facebook's algorithm, which has shifted its emphasis away from news publishers. As a result, conservative websites have seen a significant decrease in their once loyal audience. We will keep you updated on everything happening in the political world, on Fan Reviews News.")
⏲ 0:51 👁 47.1M
_9-beginner-mistakes-in-cycling-and-how-to-avoid-them.jpg "We've all been there, we've all made these mistakes when we started cycling - here's our guide to avoiding the common mistakes.")
⏲ 4:54 👁 330K
_newark-town-centre-races-2024-called-off-win-or-loss.jpg "In its weekly voxpop, the Advertiser found out what people think about Newark Town Centre Cycling Race 2024 not going ahead.")
⏲ 2:14 👁 6.9M
_celebrating-our-pets-this-national-pet-month.jpg "April is National Pet Month, so to celebrate we sent our teams out and about around the country to discover more about the nation’s favourite pets.")
⏲ 12:0 👁 1.2M
_diego-sanchez-did-steroids-in-high-school.jpg "Diego Sanchez has told the whole world for twenty years that he won the New Mexico high school state championship in wrestling with hard work and prayer. The real reason why he won the championship was because he did steroids. <br/><br/>He confesses that he wanted to be accepted in high school. He fell in with the wrong crowd and ended up working out with another student named Nick Warren. Nick found steroids for Diego and himself. They did a cycle of steroids before Diego’s senior year and as a result Diego won state. <br/><br/>Brought to you by Truth Be Told Media Network.<br/>We are working hard to bring you the truth. To support us please click here: https://ko-fi.com/truthbetoldmedianetwork<br/><br/>Truth Be Told Media Network offers new stories weekly. We are releasing a tell-all docuseries on the truth of Diego Sanchez, Joshua Fabia, and the UFC. <br/><br/>Stay tuned to watch the whole series on our website:<br/><br/>https://truthbetoldmedianetwork.com/")
⏲ 3:36 👁 270K
_e-bike-trial-for-tenby-and-other-parts-of-pembrokeshire-launched.jpg "Residents and visitors to four Pembrokeshire areas - including the seaside town of Tenby - are being invited to get on their bikes following the introduction of an exciting pay as you go E-bike trial.<br/>Thanks to funding of £150,000 from the Swansea Bay and South West Wales Metro programme, as well as Tenby, the trial will run in Haverfordwest, Fishguard andGoodwick for 12 months.<br/>The trial conducted by Pembrokeshire County Council, which starts this month, will see a fleet of E-bikes provided for members of the public to use for commuting, leisure and local activities.<br/>Users will simply be able to collect and leave E-bikes at a handy series of pick-up and drop-off sites around the towns.<br/>E-bikes are a combination of a conventional bike with a motor that take some of the effort out of pedalling for the rider. They cover greater distances in less time and with less effort than conventional cycles.<br/>The aim is to give residents and visitors an alternative method of travel rather than rely upon cars for short trips under 2km.<br/>This will in turn create a healthier and decarbonised Pembrokeshire and help towards National Decarbonisation Targets.<br/>Zipp Mobility will maintain the bikes throughout the trial period, including ensuring batteries are charged and ready to go.<br/>Cllr Rhys Sinnett, Cabinet Member for Residents’ Services said: “The successful application for the Southwest Wales Metro Funding has allowed investment in this exciting and environmentally friendly transport.<br/>“The towns will be involved in a pilot scheme to encourage residents, commuters, and visitors to utilise the electric bikes via a low-cost scheme.<br/>“We hope that if people need to do a short journey they will consider hopping on one of the conveniently placed E-bikes rather than immediately turning to a car.<br/>“If successful it is hoped that the scheme can be extended to other parts of the county”.<br/>Users will need to be over 18 and will access the E-bikes through the Zipp Mobility app via mobile phones. Download the app and register to get ready to ride. The app also provides details of costs.<br/>The E-bikes must be collected from and returned to a series of bays across each of the towns.<br/><br/>Video: ©PCC")
⏲ 2:38 👁 230K
_kyiv-group-helps-kids-cope-with-trauma-of-war-displacement.jpg "Children in Kyiv talk with DW about their pain from Russia's war in Ukraine, sharing how therapy has helped them regain strength. The loss of home, security, family and friends due to war has left them immensely traumatized.")
⏲ 3:20 👁 21.2M
_run-down-of-this-years-worldtour-bikes-124-cycling-weekly.jpg "The 2024 world tour season is finally upon us. Cycling Weekly have rounded up every single bike that will be raced in both the men's and women's world tour and broken down the specification in this video.")
⏲ 13:42 👁 1.1M
![The Daughter is a 2015 Australian drama film written and directed by Simon Stone, starring an ensemble cast led by Geoffrey Rush. The film was released in Australia on 17 March 2016 to generally favourable reviews.[2] The film is a reworking of Henrik Ibsen's 1884 play, The Wild Duck.](https://cdn6.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAaOvDGSwAv1uo_xkpxuMql9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_the-daughter-2015.jpg "The Daughter is a 2015 Australian drama film written and directed by Simon Stone, starring an ensemble cast led by Geoffrey Rush. The film was released in Australia on 17 March 2016 to generally favourable reviews.[2] The film is a reworking of Henrik Ibsen's 1884 play, The Wild Duck.")
⏲ 1:35:1 👁 520K
_re-your-eyesight.jpg "<br/>Imagine no more squinting just to read text messages, or struggling to see while driving at night without risky surgeries, expensive lenses, or lab-made pills with scary side-effects?<br/><br/>Most Americans are simply clueless to this weird scientific fact about your eyes…<br/><br/>And the true cause behind your fading vision (it has NOTHING to do with getting older)<br/><br/>In fact, this veteran military U.S. doctor challenged a billion-dollar industry just to get this information out. <br/><br/>All the while a vicious cycle attacks your eyes from the inside out, causing your vision to slowly fade away day after day…<br/><br/>It’s all explained right here.<br/><br/><br/><br/>It all has to do with this “Far East herb” known to natives as, “The Tree Of Life…”<br/><br/>That could be the key to getting your perfect vision back in as little as 7 days.<br/><br/>==> US Doctor says: \")
⏲ 1:27 👁 85K
_narrow-vs-flared-handlebars.jpg "Flared handlebars. They’ve been widely adopted in the gravel riding world, with the wider stance providing greater control on technical terrain—as well as the secondary benefit of getting your hands out the way of your bar bag.")
⏲ 7:13 👁 700K
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![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.webp "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
_pro-trump-media-sphere-imploding-in-comparison-to-2016-election-cycle.webp "The pro-Trump media landscape is experiencing a significant decline compared to the last election cycle, according to a recent report. In the lead-up to the 2016 presidential election, numerous far-right websites emerged and profited from content that supported then-candidate Donald Trump. These sites continued to generate millions of dollars during Trump's time in office. However, since the 2020 election, the flow of traffic and revenue for these right-wing media outlets has dramatically decreased. This decline can largely be attributed to changes in Facebook's algorithm, which has shifted its emphasis away from news publishers. As a result, conservative websites have seen a significant decrease in their once loyal audience. We will keep you updated on everything happening in the political world, on Fan Reviews News.")
_9-beginner-mistakes-in-cycling-and-how-to-avoid-them.webp "We've all been there, we've all made these mistakes when we started cycling - here's our guide to avoiding the common mistakes.")
_newark-town-centre-races-2024-called-off-win-or-loss.webp "In its weekly voxpop, the Advertiser found out what people think about Newark Town Centre Cycling Race 2024 not going ahead.")
_celebrating-our-pets-this-national-pet-month.webp "April is National Pet Month, so to celebrate we sent our teams out and about around the country to discover more about the nation’s favourite pets.")
_diego-sanchez-did-steroids-in-high-school.webp "Diego Sanchez has told the whole world for twenty years that he won the New Mexico high school state championship in wrestling with hard work and prayer. The real reason why he won the championship was because he did steroids. <br/><br/>He confesses that he wanted to be accepted in high school. He fell in with the wrong crowd and ended up working out with another student named Nick Warren. Nick found steroids for Diego and himself. They did a cycle of steroids before Diego’s senior year and as a result Diego won state. <br/><br/>Brought to you by Truth Be Told Media Network.<br/>We are working hard to bring you the truth. To support us please click here: https://ko-fi.com/truthbetoldmedianetwork<br/><br/>Truth Be Told Media Network offers new stories weekly. We are releasing a tell-all docuseries on the truth of Diego Sanchez, Joshua Fabia, and the UFC. <br/><br/>Stay tuned to watch the whole series on our website:<br/><br/>https://truthbetoldmedianetwork.com/")
_e-bike-trial-for-tenby-and-other-parts-of-pembrokeshire-launched.webp "Residents and visitors to four Pembrokeshire areas - including the seaside town of Tenby - are being invited to get on their bikes following the introduction of an exciting pay as you go E-bike trial.<br/>Thanks to funding of £150,000 from the Swansea Bay and South West Wales Metro programme, as well as Tenby, the trial will run in Haverfordwest, Fishguard andGoodwick for 12 months.<br/>The trial conducted by Pembrokeshire County Council, which starts this month, will see a fleet of E-bikes provided for members of the public to use for commuting, leisure and local activities.<br/>Users will simply be able to collect and leave E-bikes at a handy series of pick-up and drop-off sites around the towns.<br/>E-bikes are a combination of a conventional bike with a motor that take some of the effort out of pedalling for the rider. They cover greater distances in less time and with less effort than conventional cycles.<br/>The aim is to give residents and visitors an alternative method of travel rather than rely upon cars for short trips under 2km.<br/>This will in turn create a healthier and decarbonised Pembrokeshire and help towards National Decarbonisation Targets.<br/>Zipp Mobility will maintain the bikes throughout the trial period, including ensuring batteries are charged and ready to go.<br/>Cllr Rhys Sinnett, Cabinet Member for Residents’ Services said: “The successful application for the Southwest Wales Metro Funding has allowed investment in this exciting and environmentally friendly transport.<br/>“The towns will be involved in a pilot scheme to encourage residents, commuters, and visitors to utilise the electric bikes via a low-cost scheme.<br/>“We hope that if people need to do a short journey they will consider hopping on one of the conveniently placed E-bikes rather than immediately turning to a car.<br/>“If successful it is hoped that the scheme can be extended to other parts of the county”.<br/>Users will need to be over 18 and will access the E-bikes through the Zipp Mobility app via mobile phones. Download the app and register to get ready to ride. The app also provides details of costs.<br/>The E-bikes must be collected from and returned to a series of bays across each of the towns.<br/><br/>Video: ©PCC")
_kyiv-group-helps-kids-cope-with-trauma-of-war-displacement.webp "Children in Kyiv talk with DW about their pain from Russia's war in Ukraine, sharing how therapy has helped them regain strength. The loss of home, security, family and friends due to war has left them immensely traumatized.")
_run-down-of-this-years-worldtour-bikes-124-cycling-weekly.webp "The 2024 world tour season is finally upon us. Cycling Weekly have rounded up every single bike that will be raced in both the men's and women's world tour and broken down the specification in this video.")
![The Daughter is a 2015 Australian drama film written and directed by Simon Stone, starring an ensemble cast led by Geoffrey Rush. The film was released in Australia on 17 March 2016 to generally favourable reviews.[2] The film is a reworking of Henrik Ibsen's 1884 play, The Wild Duck.](https://cdn6.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAaOvDGSwAv1uo_xkpxuMql9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_the-daughter-2015.webp "The Daughter is a 2015 Australian drama film written and directed by Simon Stone, starring an ensemble cast led by Geoffrey Rush. The film was released in Australia on 17 March 2016 to generally favourable reviews.[2] The film is a reworking of Henrik Ibsen's 1884 play, The Wild Duck.")
_re-your-eyesight.webp "<br/>Imagine no more squinting just to read text messages, or struggling to see while driving at night without risky surgeries, expensive lenses, or lab-made pills with scary side-effects?<br/><br/>Most Americans are simply clueless to this weird scientific fact about your eyes…<br/><br/>And the true cause behind your fading vision (it has NOTHING to do with getting older)<br/><br/>In fact, this veteran military U.S. doctor challenged a billion-dollar industry just to get this information out. <br/><br/>All the while a vicious cycle attacks your eyes from the inside out, causing your vision to slowly fade away day after day…<br/><br/>It’s all explained right here.<br/><br/><br/><br/>It all has to do with this “Far East herb” known to natives as, “The Tree Of Life…”<br/><br/>That could be the key to getting your perfect vision back in as little as 7 days.<br/><br/>==> US Doctor says: \")
_narrow-vs-flared-handlebars.webp "Flared handlebars. They’ve been widely adopted in the gravel riding world, with the wider stance providing greater control on technical terrain—as well as the secondary benefit of getting your hands out the way of your bar bag.")
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