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_by-applying-the-hotel-model-this-entrepreneur-says-finding-a-nursing-home-can-be-a-joyful-process.jpg "Will Donnelly, the cofounder and CEO of Lottie, wants to make finding and booking a spot in a retirement or care home for an aging family member as easy as finding a hotel stay. In other words, \")
⏲ 16:43 👁 1.7M
_uk-man-runs-the-length-of-africa-in-less-than-a-year.jpg "UK man runs the length of Africa in less than a year! British man Russ Cook ‘Hardest Geezer’ has run from the southern tip to the northernmost point of Africa in 362 days for a fundraiser.")
⏲ 1:5 👁 7.1M
_labour-unveils-plans-to-clamp-down-on-tax-dodgers.jpg "Labour's James Murray said a Labour government will close tax loopholes that allow the mega-rich to avoid paying tax. The Shadow Treasury Minister said Labour has \")
⏲ 0:40 👁 11.9M
![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn1.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.jpg "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
⏲ 1:31 👁 14.1M
_ant-and-dec-hint-saturday-night-takeaway-might-never-return.jpg "<p>Ant and Dec admitted they don't know if they will bring back a segment on Saturday Night Takeaway as the show is \")
⏲ 0:35 👁 2.2M
_met-office-morning-weather-forecast-1392-0492-24-showery-over-the-weekend.jpg "A murky start to parts of the south coast, with cloud developing over central and northern England, as well as Wales. A band of squally rain moves across Scotland through the day, with more outbreaks of rain further south, mainly across Wales. As the bands of rain die away, showers follow behind, across Scotland and parts of northern England, Wales and Northern Ireland. The south east remains largely dry throughout the day, with the occasional spot of rain.– This is the Met Office UK Weather forecast for the morning of 13/04/24. Bringing you today’s weather forecast is Alex Burkill.<br/>")
⏲ 3:31 👁 7.3M
_a-record-of-mortals-journey-to-immortality-s3-part-2-ep-21-eng-sub.jpg "A poor and ordinary boy from a village joins a minor sect in Jiang Hu and becomes an Unofficial Disciple by chance. How will Han Li, a commoner by birth, establish a foothold for himself in in his sect? With his mediocre aptitude, he must successfully traverse the treacherous path of cultivation and avoid the notice of those who may do him harm. This is a story of an ordinary mortal who, against all odds, clashes with devilish demons and ancient celestials in order to find his own path towards immortality.<br/>")
⏲ 16:53 👁 1.9M
_the-apprentice-uk-you39re-fired-s18e11-fhd-2024.jpg "Tom Allen meets another fired candidate and shares exclusive behind-the-scenes content as Lord Sugar launches his search for a new business partner to win his £250,000 investment. A panel of special guest fans take a wry look at the week’s task, and viewers share their opinions on the candidate's progress.")
⏲ 30:0 👁 2.8M
_battle-through-the-heavens-season-5-ep-93-94-preview.jpg "Battle Through The Heavens Season 5 Ep 93-94 Preview")
⏲ 0:53 👁 840K
_iran-attacks-israel-china-russia-uk-u-s-and-other-countries-react-to-the-conflict-124-oneindia.jpg "The international community has expressed deep concern following Iran's unprecedented direct attack on Israeli territory, involving explosive drones and missile strikes. Tehran's aggression comes after an April 1 air raid, widely attributed to Israel, which resulted in the destruction of Iran's consulate in Syria and claimed the lives of 12 individuals, including two high-ranking Iranian generals. Israeli forces reported intercepting the \")
⏲ 4:39 👁 810K
_uk-restaurant-scraps-tips-for-staff-in-favour-of-a-15-brand-fee-would-you-pay-it.jpg "Do you tend to leave a tip when eating or drinking out in the UK? Fierce debates about its fairness have been sparked online in recent days, as a London restaurant has banned tipping in favour of what they're calling a brand fee.")
⏲ 1:5 👁 17M
_couple39s-getaway-ruined-after-caravan-was-so-dirty-they-had-to-clean-it-themselves.jpg "A couple say their romantic getaway was ruined after the holiday caravan was so dirty they had to clean it themselves - and the furniture broke when they used it. <br/><br/>Charmaine Bell, 30, and Natalie Berrisford, 37, splashed out £615 for what was supposed to be nice break.<br/><br/>But they say the holiday to Norfolk was ruined by the “dirt pit” caravan - which they say had wallpaper hanging off the walls, mold in the loo and a mucky fridge.<br/><br/>They say the sofas in the property were full of “hard lumps” and the bed slats were so broken they were left sleeping at an angle.<br/><br/>Despite complaining to the holiday company, 2C Holidays, they say they had to stay in the “filthy” caravan for nine nights. <br/><br/>Charmaine, from Royston, Herts., said: “It's really upset me and my partner, we’ve been together 13 years and thought we’d have a nice holiday with the dogs. <br/><br/>“From the second we got to the caravan and walked in it was dirty. <br/><br/>“There was wallpaper coming away from walls, mold in the corners of the room and under the lid of the toilet, the sides were dirty, and the fridge had sticky stuff in it, it was filthy. <br/><br/>“The sofas had really big hard lumps in bottom of them - every time we sat down, we were sat on an angle.” <br/><br/>The couple arrived in Hemsby for a romantic getaway on March 6 – but say as soon as they walked into the caravan at the holiday park they found it filthy.<br/><br/>They say they were looking forwards to spending quality time together with their dogs, with Nathalie travelling down from Scotland for the trip.<br/><br/>But they say when they complained to 2C Holidays about the conditions, they were told they could clean it themselves or spend another £300 to be upgraded to a new caravan. <br/><br/>Charmaine said she decided to clean herself – and says the company offered her £50 for her efforts. <br/><br/>The couple say at the end of their stay they were offered £75 compensation – but claim after the £50 for cleaning, this leaves just £25 for their inconvenience.<br/><br/>“We couldn't pay out for a new caravan, there was literally nowhere else we could go, so it was very upsetting,” said Charmaine.<br/><br/>“Nathalie had a serious back surgery a couple of years ago and she nearly went through the bed. <br/><br/>“She came down from Scotland and this happened, it was just so upsetting, we were literally trapped there.” <br/><br/>A spokesperson for 2C Holidays said: \")
⏲ 4:11 👁 780K
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_by-applying-the-hotel-model-this-entrepreneur-says-finding-a-nursing-home-can-be-a-joyful-process.webp "Will Donnelly, the cofounder and CEO of Lottie, wants to make finding and booking a spot in a retirement or care home for an aging family member as easy as finding a hotel stay. In other words, \")
_uk-man-runs-the-length-of-africa-in-less-than-a-year.webp "UK man runs the length of Africa in less than a year! British man Russ Cook ‘Hardest Geezer’ has run from the southern tip to the northernmost point of Africa in 362 days for a fundraiser.")
_labour-unveils-plans-to-clamp-down-on-tax-dodgers.webp "Labour's James Murray said a Labour government will close tax loopholes that allow the mega-rich to avoid paying tax. The Shadow Treasury Minister said Labour has \")
![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn1.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.webp "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
_ant-and-dec-hint-saturday-night-takeaway-might-never-return.webp "<p>Ant and Dec admitted they don't know if they will bring back a segment on Saturday Night Takeaway as the show is \")
_met-office-morning-weather-forecast-1392-0492-24-showery-over-the-weekend.webp "A murky start to parts of the south coast, with cloud developing over central and northern England, as well as Wales. A band of squally rain moves across Scotland through the day, with more outbreaks of rain further south, mainly across Wales. As the bands of rain die away, showers follow behind, across Scotland and parts of northern England, Wales and Northern Ireland. The south east remains largely dry throughout the day, with the occasional spot of rain.– This is the Met Office UK Weather forecast for the morning of 13/04/24. Bringing you today’s weather forecast is Alex Burkill.<br/>")
_a-record-of-mortals-journey-to-immortality-s3-part-2-ep-21-eng-sub.webp "A poor and ordinary boy from a village joins a minor sect in Jiang Hu and becomes an Unofficial Disciple by chance. How will Han Li, a commoner by birth, establish a foothold for himself in in his sect? With his mediocre aptitude, he must successfully traverse the treacherous path of cultivation and avoid the notice of those who may do him harm. This is a story of an ordinary mortal who, against all odds, clashes with devilish demons and ancient celestials in order to find his own path towards immortality.<br/>")
_the-apprentice-uk-you39re-fired-s18e11-fhd-2024.webp "Tom Allen meets another fired candidate and shares exclusive behind-the-scenes content as Lord Sugar launches his search for a new business partner to win his £250,000 investment. A panel of special guest fans take a wry look at the week’s task, and viewers share their opinions on the candidate's progress.")
_battle-through-the-heavens-season-5-ep-93-94-preview.webp "Battle Through The Heavens Season 5 Ep 93-94 Preview")
_iran-attacks-israel-china-russia-uk-u-s-and-other-countries-react-to-the-conflict-124-oneindia.webp "The international community has expressed deep concern following Iran's unprecedented direct attack on Israeli territory, involving explosive drones and missile strikes. Tehran's aggression comes after an April 1 air raid, widely attributed to Israel, which resulted in the destruction of Iran's consulate in Syria and claimed the lives of 12 individuals, including two high-ranking Iranian generals. Israeli forces reported intercepting the \")
_uk-restaurant-scraps-tips-for-staff-in-favour-of-a-15-brand-fee-would-you-pay-it.webp "Do you tend to leave a tip when eating or drinking out in the UK? Fierce debates about its fairness have been sparked online in recent days, as a London restaurant has banned tipping in favour of what they're calling a brand fee.")
_couple39s-getaway-ruined-after-caravan-was-so-dirty-they-had-to-clean-it-themselves.webp "A couple say their romantic getaway was ruined after the holiday caravan was so dirty they had to clean it themselves - and the furniture broke when they used it. <br/><br/>Charmaine Bell, 30, and Natalie Berrisford, 37, splashed out £615 for what was supposed to be nice break.<br/><br/>But they say the holiday to Norfolk was ruined by the “dirt pit” caravan - which they say had wallpaper hanging off the walls, mold in the loo and a mucky fridge.<br/><br/>They say the sofas in the property were full of “hard lumps” and the bed slats were so broken they were left sleeping at an angle.<br/><br/>Despite complaining to the holiday company, 2C Holidays, they say they had to stay in the “filthy” caravan for nine nights. <br/><br/>Charmaine, from Royston, Herts., said: “It's really upset me and my partner, we’ve been together 13 years and thought we’d have a nice holiday with the dogs. <br/><br/>“From the second we got to the caravan and walked in it was dirty. <br/><br/>“There was wallpaper coming away from walls, mold in the corners of the room and under the lid of the toilet, the sides were dirty, and the fridge had sticky stuff in it, it was filthy. <br/><br/>“The sofas had really big hard lumps in bottom of them - every time we sat down, we were sat on an angle.” <br/><br/>The couple arrived in Hemsby for a romantic getaway on March 6 – but say as soon as they walked into the caravan at the holiday park they found it filthy.<br/><br/>They say they were looking forwards to spending quality time together with their dogs, with Nathalie travelling down from Scotland for the trip.<br/><br/>But they say when they complained to 2C Holidays about the conditions, they were told they could clean it themselves or spend another £300 to be upgraded to a new caravan. <br/><br/>Charmaine said she decided to clean herself – and says the company offered her £50 for her efforts. <br/><br/>The couple say at the end of their stay they were offered £75 compensation – but claim after the £50 for cleaning, this leaves just £25 for their inconvenience.<br/><br/>“We couldn't pay out for a new caravan, there was literally nowhere else we could go, so it was very upsetting,” said Charmaine.<br/><br/>“Nathalie had a serious back surgery a couple of years ago and she nearly went through the bed. <br/><br/>“She came down from Scotland and this happened, it was just so upsetting, we were literally trapped there.” <br/><br/>A spokesperson for 2C Holidays said: \")
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