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![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.jpg "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
⏲ 1:31 👁 14.2M
_couple39s-getaway-ruined-after-caravan-was-so-dirty-they-had-to-clean-it-themselves.jpg "A couple say their romantic getaway was ruined after the holiday caravan was so dirty they had to clean it themselves - and the furniture broke when they used it. <br/><br/>Charmaine Bell, 30, and Natalie Berrisford, 37, splashed out £615 for what was supposed to be nice break.<br/><br/>But they say the holiday to Norfolk was ruined by the “dirt pit” caravan - which they say had wallpaper hanging off the walls, mold in the loo and a mucky fridge.<br/><br/>They say the sofas in the property were full of “hard lumps” and the bed slats were so broken they were left sleeping at an angle.<br/><br/>Despite complaining to the holiday company, 2C Holidays, they say they had to stay in the “filthy” caravan for nine nights. <br/><br/>Charmaine, from Royston, Herts., said: “It's really upset me and my partner, we’ve been together 13 years and thought we’d have a nice holiday with the dogs. <br/><br/>“From the second we got to the caravan and walked in it was dirty. <br/><br/>“There was wallpaper coming away from walls, mold in the corners of the room and under the lid of the toilet, the sides were dirty, and the fridge had sticky stuff in it, it was filthy. <br/><br/>“The sofas had really big hard lumps in bottom of them - every time we sat down, we were sat on an angle.” <br/><br/>The couple arrived in Hemsby for a romantic getaway on March 6 – but say as soon as they walked into the caravan at the holiday park they found it filthy.<br/><br/>They say they were looking forwards to spending quality time together with their dogs, with Nathalie travelling down from Scotland for the trip.<br/><br/>But they say when they complained to 2C Holidays about the conditions, they were told they could clean it themselves or spend another £300 to be upgraded to a new caravan. <br/><br/>Charmaine said she decided to clean herself – and says the company offered her £50 for her efforts. <br/><br/>The couple say at the end of their stay they were offered £75 compensation – but claim after the £50 for cleaning, this leaves just £25 for their inconvenience.<br/><br/>“We couldn't pay out for a new caravan, there was literally nowhere else we could go, so it was very upsetting,” said Charmaine.<br/><br/>“Nathalie had a serious back surgery a couple of years ago and she nearly went through the bed. <br/><br/>“She came down from Scotland and this happened, it was just so upsetting, we were literally trapped there.” <br/><br/>A spokesperson for 2C Holidays said: \")
⏲ 4:11 👁 875K
_uk-restaurant-scraps-tips-for-staff-in-favour-of-a-15-brand-fee-would-you-pay-it.jpg "Do you tend to leave a tip when eating or drinking out in the UK? Fierce debates about its fairness have been sparked online in recent days, as a London restaurant has banned tipping in favour of what they're calling a brand fee.")
⏲ 1:5 👁 17.2M
_farmer-says-after-92.jpg "A farmer of 45 years today told how this winter had been the worst he had ever experienced and how it had destroyed much of his crop <br/><br/>George Munns, 62,said it is a miracle any of his sugar beet crop survived after a difficult winter season left his fields under water.<br/><br/>George lost up to 400 tonnes of sugar beet after the wet winter left a field under two feet of water for nearly five months.<br/><br/>The farmer of 45 years had expected a yield of 700 tonnes from the worst waterlogged field and said there has \")
⏲ 0:43 👁 10.6M
_hoo-zoo-and-dinosaur-world-telford-have-been-named-second-best-zoo-in-the-uk-for-the-second-time.jpg "Hoo Zoo and Dinosaur World, Telford have been named second best zoo in the UK for the second time. The Shropshire Star talk to visitors to find out what makes it so special.")
⏲ 4:57 👁 1.9M
_chinese-russian-top-diplomats-meet-to-deepen-ties.jpg "Chinese, Russian top diplomats meet to deepen ties<br/><br/>Russian Foreign Minister Sergei Lavrov meets with Chinese counterpart Wang Yi to enhance cooperation amidst Russia's increasing isolation due to the Ukraine war. Both countries have been strengthening diplomatic relations, aligning against the West and the United States.<br/><br/>Video by AFP<br/><br/>Subscribe to The Manila Times Channel - https://tmt.ph/YTSubscribe <br/> <br/>Visit our website at https://www.manilatimes.net <br/> <br/>Follow us: <br/>Facebook - https://tmt.ph/facebook <br/>Instagram - https://tmt.ph/instagram <br/>Twitter - https://tmt.ph/twitter <br/>DailyMotion - https://tmt.ph/dailymotion <br/> <br/>Subscribe to our Digital Edition - https://tmt.ph/digital <br/> <br/>Check out our Podcasts: <br/>Spotify - https://tmt.ph/spotify <br/>Apple Podcasts - https://tmt.ph/applepodcasts <br/>Amazon Music - https://tmt.ph/amazonmusic <br/>Deezer: https://tmt.ph/deezer <br/>Tune In: https://tmt.ph/tunein<br/> <br/>#TheManilaTimes<br/>#tmtnews <br/>#china <br/>#russia")
⏲ 1:52 👁 2.5M
_us-historians-inform-supreme-court-that-they-reject-trumps-immunity-claim.jpg "US Historians Inform Supreme Court , That They Reject Trump’s Immunity Claim.<br/>Former President Donald Trump faces multiple federal election interference charges stemming <br/>from his attempt to overturn the 2020 election.<br/>He and his legal team assert that he is immune to prosecution since he was president at the time.<br/>But 15 historians have since \")
⏲ 1:31 👁 33.4M
_damage-to-showton-museum-closes-bank-hey-street.jpg "The signage on the Showton Museum appears to have been damaged by the wind.")
⏲ 0:24 👁 32.1M
_ex-ohtani-interpreter-likely-to-face-federal-charges-sources-say.jpg "Ex-Ohtani Interpreter , Likely to Face Federal Charges, Sources Say.<br/>NBC reports that Shohei Ohtani's former interpreter <br/>may face federal charges in connection with a <br/>gambling investigation into a California bookie. .<br/>According to sources, Ohtani has <br/>been assisting with the investigation.<br/>The news from NBC follows a similar report by TMZ <br/>that Ippei Mizuhara, the former Ohtani interpreter, <br/>will be facing charges by federal authorities.<br/>On March 21, Mizuhara was fired by the L.A. Dodgers <br/>after attorneys representing Ohtani alleged <br/>\")
⏲ 1:30 👁 3M
_worlds-fastest-porsche-hits-227mph.jpg "For 15 years, BBI Autosport have been the experts in high-end, off-the-market tuning. But one of their most recent projects on a Porsche 911 GT2 RS seems to have stood out from the rest. Although this model is already Porsche’s most powerful car, BBI has expanded its capability even further by transforming one from a sleek sports car into a swift supercar. With specialist customisation, they pushed the car to reach speeds of 227mph, making it the fastest 911 in the world. Owner of BBI Betim Berisha told R.Rides: “We take this beautiful canvas that Porsche gives us and we tailor it to a client’s need or specific goal that we’re after. I don’t think we have ever built a car that made you actually feel this comfortable doing something so wrong. If I had to describe this Porsche in three words, I would say it’s visceral, raw and powerful.” Starting with the factory model, BBI upgraded the classic 911 with a custom engine, larger turbos and an advanced cooling system. Dmitriy Orlov, who works at the company said: “This car has bigger turbochargers, more intercooler, better calibration, a water-methanol injection system, better chassis to handle the high speed – and of course on Michelin tyres because they are just proven to be phenomenal at any speed and power level. There is also a lot of work on the interior. There are raised seats and harnesses to ensure that the car is safe.” To buy from the showroom, the Porsche 911 GT2 RS typically sells for around $350,000 – but with this level of modification, this car would cost closer to half a million dollars.")
⏲ 5:26 👁 8.7M
_tot-born-with-1kg-cyst-under-her-arm-so-heavy-it39s-making-her-spine-curve.jpg "A toddler born with a cyst the size of a pineapple under her arm is so heavy her spine has started to curve.<br/><br/>Jessi Campbell, two, was born with an estimated 1kg growth on her left arm, chest and fingers.<br/><br/>She was diagnosed with lymphatic malformation before birth – where lymph vessels form abnormally – and Kippel-Trelauney Syndrome at 11-months-old in July 2022. <br/><br/>The syndrome is a collection of symptoms - port wine stains, varicose veins and hypertrophy which is the extra growth of a limb. <br/><br/>Jessi has had three rounds of sclerotherapy – where a solution is injected into the veins to make the lymph collapse and shrink the cyst - and will continue to have more.<br/><br/>She took longer to walk – due to her balance – and is now struggling with a curved spine due to the weight of her arm. <br/><br/>The weight of her arm changes \")
⏲ 0:46 👁 6.5M
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![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.webp "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
_couple39s-getaway-ruined-after-caravan-was-so-dirty-they-had-to-clean-it-themselves.webp "A couple say their romantic getaway was ruined after the holiday caravan was so dirty they had to clean it themselves - and the furniture broke when they used it. <br/><br/>Charmaine Bell, 30, and Natalie Berrisford, 37, splashed out £615 for what was supposed to be nice break.<br/><br/>But they say the holiday to Norfolk was ruined by the “dirt pit” caravan - which they say had wallpaper hanging off the walls, mold in the loo and a mucky fridge.<br/><br/>They say the sofas in the property were full of “hard lumps” and the bed slats were so broken they were left sleeping at an angle.<br/><br/>Despite complaining to the holiday company, 2C Holidays, they say they had to stay in the “filthy” caravan for nine nights. <br/><br/>Charmaine, from Royston, Herts., said: “It's really upset me and my partner, we’ve been together 13 years and thought we’d have a nice holiday with the dogs. <br/><br/>“From the second we got to the caravan and walked in it was dirty. <br/><br/>“There was wallpaper coming away from walls, mold in the corners of the room and under the lid of the toilet, the sides were dirty, and the fridge had sticky stuff in it, it was filthy. <br/><br/>“The sofas had really big hard lumps in bottom of them - every time we sat down, we were sat on an angle.” <br/><br/>The couple arrived in Hemsby for a romantic getaway on March 6 – but say as soon as they walked into the caravan at the holiday park they found it filthy.<br/><br/>They say they were looking forwards to spending quality time together with their dogs, with Nathalie travelling down from Scotland for the trip.<br/><br/>But they say when they complained to 2C Holidays about the conditions, they were told they could clean it themselves or spend another £300 to be upgraded to a new caravan. <br/><br/>Charmaine said she decided to clean herself – and says the company offered her £50 for her efforts. <br/><br/>The couple say at the end of their stay they were offered £75 compensation – but claim after the £50 for cleaning, this leaves just £25 for their inconvenience.<br/><br/>“We couldn't pay out for a new caravan, there was literally nowhere else we could go, so it was very upsetting,” said Charmaine.<br/><br/>“Nathalie had a serious back surgery a couple of years ago and she nearly went through the bed. <br/><br/>“She came down from Scotland and this happened, it was just so upsetting, we were literally trapped there.” <br/><br/>A spokesperson for 2C Holidays said: \")
_uk-restaurant-scraps-tips-for-staff-in-favour-of-a-15-brand-fee-would-you-pay-it.webp "Do you tend to leave a tip when eating or drinking out in the UK? Fierce debates about its fairness have been sparked online in recent days, as a London restaurant has banned tipping in favour of what they're calling a brand fee.")
_farmer-says-after-92.webp "A farmer of 45 years today told how this winter had been the worst he had ever experienced and how it had destroyed much of his crop <br/><br/>George Munns, 62,said it is a miracle any of his sugar beet crop survived after a difficult winter season left his fields under water.<br/><br/>George lost up to 400 tonnes of sugar beet after the wet winter left a field under two feet of water for nearly five months.<br/><br/>The farmer of 45 years had expected a yield of 700 tonnes from the worst waterlogged field and said there has \")
_hoo-zoo-and-dinosaur-world-telford-have-been-named-second-best-zoo-in-the-uk-for-the-second-time.webp "Hoo Zoo and Dinosaur World, Telford have been named second best zoo in the UK for the second time. The Shropshire Star talk to visitors to find out what makes it so special.")
_chinese-russian-top-diplomats-meet-to-deepen-ties.webp "Chinese, Russian top diplomats meet to deepen ties<br/><br/>Russian Foreign Minister Sergei Lavrov meets with Chinese counterpart Wang Yi to enhance cooperation amidst Russia's increasing isolation due to the Ukraine war. Both countries have been strengthening diplomatic relations, aligning against the West and the United States.<br/><br/>Video by AFP<br/><br/>Subscribe to The Manila Times Channel - https://tmt.ph/YTSubscribe <br/> <br/>Visit our website at https://www.manilatimes.net <br/> <br/>Follow us: <br/>Facebook - https://tmt.ph/facebook <br/>Instagram - https://tmt.ph/instagram <br/>Twitter - https://tmt.ph/twitter <br/>DailyMotion - https://tmt.ph/dailymotion <br/> <br/>Subscribe to our Digital Edition - https://tmt.ph/digital <br/> <br/>Check out our Podcasts: <br/>Spotify - https://tmt.ph/spotify <br/>Apple Podcasts - https://tmt.ph/applepodcasts <br/>Amazon Music - https://tmt.ph/amazonmusic <br/>Deezer: https://tmt.ph/deezer <br/>Tune In: https://tmt.ph/tunein<br/> <br/>#TheManilaTimes<br/>#tmtnews <br/>#china <br/>#russia")
_us-historians-inform-supreme-court-that-they-reject-trumps-immunity-claim.webp "US Historians Inform Supreme Court , That They Reject Trump’s Immunity Claim.<br/>Former President Donald Trump faces multiple federal election interference charges stemming <br/>from his attempt to overturn the 2020 election.<br/>He and his legal team assert that he is immune to prosecution since he was president at the time.<br/>But 15 historians have since \")
_damage-to-showton-museum-closes-bank-hey-street.webp "The signage on the Showton Museum appears to have been damaged by the wind.")
_ex-ohtani-interpreter-likely-to-face-federal-charges-sources-say.webp "Ex-Ohtani Interpreter , Likely to Face Federal Charges, Sources Say.<br/>NBC reports that Shohei Ohtani's former interpreter <br/>may face federal charges in connection with a <br/>gambling investigation into a California bookie. .<br/>According to sources, Ohtani has <br/>been assisting with the investigation.<br/>The news from NBC follows a similar report by TMZ <br/>that Ippei Mizuhara, the former Ohtani interpreter, <br/>will be facing charges by federal authorities.<br/>On March 21, Mizuhara was fired by the L.A. Dodgers <br/>after attorneys representing Ohtani alleged <br/>\")
_worlds-fastest-porsche-hits-227mph.webp "For 15 years, BBI Autosport have been the experts in high-end, off-the-market tuning. But one of their most recent projects on a Porsche 911 GT2 RS seems to have stood out from the rest. Although this model is already Porsche’s most powerful car, BBI has expanded its capability even further by transforming one from a sleek sports car into a swift supercar. With specialist customisation, they pushed the car to reach speeds of 227mph, making it the fastest 911 in the world. Owner of BBI Betim Berisha told R.Rides: “We take this beautiful canvas that Porsche gives us and we tailor it to a client’s need or specific goal that we’re after. I don’t think we have ever built a car that made you actually feel this comfortable doing something so wrong. If I had to describe this Porsche in three words, I would say it’s visceral, raw and powerful.” Starting with the factory model, BBI upgraded the classic 911 with a custom engine, larger turbos and an advanced cooling system. Dmitriy Orlov, who works at the company said: “This car has bigger turbochargers, more intercooler, better calibration, a water-methanol injection system, better chassis to handle the high speed – and of course on Michelin tyres because they are just proven to be phenomenal at any speed and power level. There is also a lot of work on the interior. There are raised seats and harnesses to ensure that the car is safe.” To buy from the showroom, the Porsche 911 GT2 RS typically sells for around $350,000 – but with this level of modification, this car would cost closer to half a million dollars.")
_tot-born-with-1kg-cyst-under-her-arm-so-heavy-it39s-making-her-spine-curve.webp "A toddler born with a cyst the size of a pineapple under her arm is so heavy her spine has started to curve.<br/><br/>Jessi Campbell, two, was born with an estimated 1kg growth on her left arm, chest and fingers.<br/><br/>She was diagnosed with lymphatic malformation before birth – where lymph vessels form abnormally – and Kippel-Trelauney Syndrome at 11-months-old in July 2022. <br/><br/>The syndrome is a collection of symptoms - port wine stains, varicose veins and hypertrophy which is the extra growth of a limb. <br/><br/>Jessi has had three rounds of sclerotherapy – where a solution is injected into the veins to make the lymph collapse and shrink the cyst - and will continue to have more.<br/><br/>She took longer to walk – due to her balance – and is now struggling with a curved spine due to the weight of her arm. <br/><br/>The weight of her arm changes \")
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