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Latest in PARP inhibitors and combination therapies for prostate cancer
⏲ 13 min 43 sec ✓ 19-Feb-2023
PARP inhibitor olaparib as treatment for pancreatic cancer patients with BRCA gene mutations
⏲ 1 min 78 sec ✓ 02-Jun-2019
Niacin is neuroprotective in a fly model of Parkinson’s disease
⏲ 1 min 54 sec ✓ 22-Dec-2016
Part 1 -DNA Damage Response and PARP inhibition
⏲ 1 min 85 sec ✓ 09-Jul-2019
Immunomodulatory effects of PARP inhibition in BRCA1-deficient triple-negative breast cancer
⏲ 1 min 67 sec ✓ 09-Apr-2019
ASCO 2022: Latest in prostate cancer, including PARP inhibitors
⏲ 16 min 96 sec ✓ 06-Jun-2022
PARP11
⏲ 3 min 14 sec ✓ 26-Mar-2008
PARP inhibitor olaparib slows progression of advanced prostate cancer
⏲ 5 min 38 sec ✓ 30-Sep-2019
Breast cancer treatment
⏲ 2 min 10 sec ✓ 26-Jul-2011
PARP Inhibitor Maintenance Therapy for Pancreatic Cancer With BRCA Mutation
⏲ 1 min 51 sec ✓ 14-Sep-2019
PARP inhibitors and their evolving role for the treatment of prostate cancer
⏲ 23 min 26 sec ✓ 24-Sep-2020
PARP - Inspiracje - Odblaski | Darek Zatorski
⏲ 30 sec ✓ 21-Feb-2013
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_latest-in-parp-inhibitors-and-combination-therapies-for-prostate-cancer.webp "Dr Dan George (Duke University School of Medicine, USA), Prof Noel Clarke (The Christie NHS Foundation Trust, Manchester, UK), Dr Friederike Schlurmann (Centre Hospitalier Universitaire de Brest, Brest, France) and Prof Eleni Efstathiou (Houston Methodist Cancer Center, Houston, USA) discuss the latest in PARP inhibitors and combinations for prostate cancer. nnIn this discussion they cover the TALAPRO-2, PROpel and MAGNITUDE trials. They discuss the use of non-OS endpoints and combination therap")
_parp-inhibitor-olaparib-as-treatment-for-pancreatic-cancer-patients-with-brca-gene-mutations.webp "Dr Hedy Kindler talks to ecancer at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting about results from the POLO trial looking at the use of the PARP inhibitor olaparib as treatment for pancreatic cancer patients with BRCA gene mutationsnnShe explains that this trial is the first phase III trial showing that a targeted treatment in a biomarker selective group of pancreatic cancer patients can improve progression free survival.nnDr Kindler reports that patients who received ol")
_niacin-is-neuroprotective-in-a-fly-model-of-parkinsons-disease.webp "https://doi.org/10.1242/bio.022186nnLehmann et al.")
_part-1-dna-damage-response-and-parp-inhibition.webp "Short chapter from the Mechanism of Action of PARP inhibitors and Targeting DNA Damage Response (DDR) video")
_immunomodulatory-effects-of-parp-inhibition-in-brca1-deficient-triple-negative-breast-cancer.webp "Dr Constantia Pantelidou speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about a study which looked at the immunomodulatory effects of PARP inhibition in BRCA1-deficient triple-negative breast cancer (TNBC).nnShe reports that PARP inhibitors induce an anti-tumour immune response in BRCA1-deficient TNBC but not in BRCA1-proficient TNBC.nnDr Pantelidou explains that this T cell recruitment is mediated through activation of the STING pathway and this activation")
_asco-2022-latest-in-prostate-cancer-including-parp-inhibitors.webp "Dr Neal Shore (Carolina Urologic Research Center, Myrtle Beach, USA), Prof Phil Cornford (Royal Liverpool University Hospital, Liverpool, UK), Prof Eleni Efstathiou (Houston Methodist Cancer Center, Houston, USA) and Prof Cora Sternberg (Weill Cornell Medicine, New York, USA) discuss the latest in prostate cancer, including PARP inhibitors. nnInitially, they discuss the latest trials and updates in prostate cancer including PROPEL, MAGNITUDE and the ARCHES trial.nnThey discuss the use of Lutetiu")
_parp11.webp "PARP11 from parp")
_parp-inhibitor-olaparib-slows-progression-of-advanced-prostate-cancer.webp "Prof Maha Hussain presents data from thePROfound trial during a press conference at the 2019 ESMO congress.nnThis was a trial evaluating the PARP inhibitor olaparib vs new hormonal agents in patients with metastatic, pre-treated prostate cancer whose cancer cells had faulty DNA repair genes.nnSign up to ecancer for free to receive tailored email alerts for more videos like this.necancer.org/account/register.php")
_breast-cancer-treatment.webp "Animation showing a drug MOA for treating breast cancer.")
_parp-inhibitor-maintenance-therapy-for-pancreatic-cancer-with-brca-mutation.webp "At the 2019 Great Debates and Updates in GI Malignancies meeting, Eileen O'Reilly, MD, debated in favor of using PARP inhibitors as maintenance therapy for patients with BRCA mutation–positive pancreatic cancer.")
_parp-inhibitors-and-their-evolving-role-for-the-treatment-of-prostate-cancer.webp "Drs Shore, Agarwal, Castro and Chi discuss the latest in PARP inhibitors in prostate cancer.nnStarting with some background on the science involved in PARP inhibition, they cover some of the major studies presented at ESMO 2020:nn- PROfoundn- TALAPRO-1n- KEYNOTE-365n- TRITON2n- NADIRnnThe panel discuss the science behind the studies and their potential impact on clinical practice from a global perspective.nnThey cover the increasing importance of testing, the differ")
_parp-inspiracje-odblaski-124-darek-zatorski.webp "PARP - Inspiracje - Odblaskindir: Darek Zatorskinnprezentacja dorobku - creative showcasenpoint of you")
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