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Messenger RNA (mRNA) therapeutics have shown great promise for expressing functional proteins. However, the efficient and safe delivery of mRNA remains a key challenge for the clinical application of mRNA based therapeutics. In order to improve mRNA delivery, we designed N1,N3,N5-tris(2-aminoethyl)benzene-1,3,5-tricarboxamide (TT) derived lipids. We applied an orthogonal experimental design to investigate the impacts of formulation components on delivery efficiency. In a hemophilia mouse model,

Development of Nanomaterials for mRNA Therapeutics and Genome Editing - Yizhou Dong

⏲ 22 min 10 sec ✓ 18-Oct-2019

Freesciencelessons

A Level Chemistry Revision (Year 13) \"The Structure of Benzene\"

⏲ 5 minutes 👁 8.2K

Chemistry Student

Benzene Structure and Bonding (A-Level Chemistry)

⏲ 12 minutes 33 seconds 👁 4.3K

The KTM 390 Duke is an aggressively styled naked bike that embodies these qualities, offering a peppy riding experience for new riders, and anyone seeking a compact, easy-riding streetbike for around-town use.<br/><br/>Read the best motorcycle news and reviews: http://www.motorcyclistonline.com/<br/><br/>Motorcyclist Shirts: https://teespring.com/stores/motorcyclist<br/>Instagram: https://www.instagram.com/motorcyclistonline/<br/>Facebook: https://www.facebook.com/motorcyclistmag/

Is The KTM 390 Duke The Most Advanced Entry Level Motorcycle?

⏲ 13:32 👁 78M

Eliot Rintoul

AQA A-Level Chemistry - Aromatic Chemistry 1 (Benzene Structure)

⏲ 19 minutes 34 seconds 👁 63.7K

Allery Chemistry

Benzene - Structure and stability

⏲ 9 minutes 31 seconds 👁 37.8K

A studio that resembles a garden shed in south-east London is being rented out for £1,300-a-month in the latest evidence of the grim situation facing capital’s renters.Marketed as an “outstanding studio annexe”, the small timber-clad structure sits at the bottom of the back garden of a semi-detached house in Abbey Wood.

London rental crisis: 'Outstanding studio' that looks like garden shed being rented at £1,300-a-month

⏲ 0:57 👁 24.7M

Tailored Tutors

Benzene Structure | A Level Chemistry

⏲ 9 minutes 31 seconds 👁 646

SnapRevise

Benzene | A-level Chemistry | AQA, OCR, Edexcel

⏲ 2 minutes 55 seconds 👁 3K

Police are investigating after a Tasmanian man jumped out of his car at a level crossing, narrowly avoiding being hit by a train.

Man jumps out of car just before it got hit by train

⏲ 1:16 👁 3M

SnapRevise

Kekule Structure of Benzene | A-level Chemistry | OCR, AQA, Edexcel

⏲ 8 minutes 55 seconds 👁 30.1K

The Organic Chemistry Tutor

Organic Chemistry

⏲ 53 minutes 35 seconds 👁 1.2M

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